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Pinocembrin accelerates the regression of xenografted keloid tissues and reduces ECM gene expression. (A) Macrographic examination of xenografted tissues on the back of nude BALB/c mice. (B) Weight of xenografted tissues after intralesional injection of pinocembrin. (C) mRNA levels of α-SMA, Col1α1, Col3α1, and Fn in xenografted keloid tissues were assessed by qPCR. Means± SD, n = 4. * p < 0.05, ** p < 0.01, *** p < 0.001.
