Figure 3.

Cerebral Metabolic rates of glucose oxidation (CMR_Glc(Ox)) in (a) Cerebral cortex and (b) Hippocampus of ICV-STZ (3 mg/kg) treated mice. The ¹³C labeling of amino acids from [1,6-¹³C₂]glucose was measured in the tissue extracts using ¹H-[¹³C]-NMR spectroscopy. The CMR_Glc(Ox) was calculated using equations (4) to (6). The vertical bar represents the mean±SD of the group, while the symbols depict individual values. *p < 0.05 and **p < 0.01 when ICV-STZ-treated mice were compared with controls.