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The correlation between memory and neurometabolic measures (● CMRGlc, ▲ CMRGlc(Glu), ♦ CMRGlc(GABA)) in (a) Cerebral cortex and (b) Hippocampus of control and ICV-STZ-treated (5 mg/kg) mice. Discrimination Index (DI) was calculated using equation (2), based on the frequency of animals towards novel object in the novel object recognition test. The cerebral rates of glucose oxidation were measured from the 13C labeling of amino acids from [1,6-13C2]glucose using equations (4) to (6).
