Table 2.

The twelve most referenced human rRNA 2′Ome sites showing variability.

Site 1	Biological Context of Variability	Variation	Related snoRNA (Host Gene)	Method	Reference
18S-Um116	FBL depletion	Down	SNORD42A/B	RMS 2-Illumina	[44]
	SNORD42A depletion	Down	(RPL23A)	RMS-Illumina + RTL-P	[54]
	EZH2 depletion	Down		RMS-Illumina	[50]
	Cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
18S-Cm174	FMRP depletion	Up	SNORD45C	RMS-Illumina	[51]
	FBL depletion	Down	(RABGGTB)	RMS-Illumina	[44]
	c-MYC overexpression	Up		RMS-Ion Torrent	[59]
	EZH2 depletion	Down		RMS-Illumina	[50]
	Cell lines	Up and down		RMS-Ion Torrent	[26]
18S-Gm867	FMRP depletion	Down	SNORD98	RMS-Illumina	[51]
	EZH2 depletion	Down	(CCAR1)	RMS-Illumina	[50]
	FBL depletion	Down		RMS-Illumina	[44]
	Cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
28S-Cm1327	EZH2 depletion	Down	SNORD104	RMS-Illumina	[50]
	NPM1 depletion and loss-of-function, between AML patients	Down	(lncSNHG25)	RTL-P	[52]
	FBL depletion	Down		RMS-Illumina	[44]
	Cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
28S-Am1858	Reduced Arl2 expression	Up	SNORD38A/B	RTL-P	[64]
	FBL depletion	Down	(RPS8)	RMS-Illumina	[44]
	EZH2 depletion	Down		RMS-Illumina	[50]
	DLBCL patients vs. healthy donor	Down		RMS-Ion Torrent	[70]
	ß-thalassemic patients vs. healthy donor	Up		RTL-P	[69]
28S-Um2402	FMRP depletion	Down	SNORD143, SNORD144	RMS-Illumina	[51]
	FBL depletion	Down	(SEC31A)	RMS-Illumina	[44]
	c-MYC overexpression	Down		RMS-Ion Torrent	[59]
	cell lines	Up and down		RMS-Ion Torrent	[26]
	Cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
	DLBCL patients vs. healthy donor	Down		RMS-Ion Torrent	[70]
28S-Cm2409	EZH2 depletion	Down	SNORD5	RMS-Illumina	[50]
	FMRP depletion	Up	(TAF1D)	RMS-Illumina	[51]
	FBL depletion	Down		RMS-Illumina	[44]
	cell lines	Up and down		RMS-Ion Torrent	[26]
	cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
28S-Am2774	FMRP depletion	Down	SNORD99	RMS-Illumina	[51]
	FBL depletion	Down	(SNHG12)	RMS-Illumina	[44]
	Cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
	Brain, liver and skeletal muscle	Down in Liver		RMS-Ion Torrent	[70]
28S-Cm2848	EZH2 depletion	Down	SNORD50A/B	RMS-Illumina	[50]
	FBL depletion	Down	(SNHG5)	RMS-Illumina	[44]
	Cell lines	Up and down		RMS-Ion Torrent	[26]
	Cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
28S-Gm3923	FMRP depletion	Down	SNORD111/B	RMS-Illumina	[51]
	FBL depletion	Down	(SF3B3)	RMS-Illumina	[44]
	Cell lines	Up and down		RMS-Ion Torrent	[26]
	cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
28S-Cm4506	FBL depletion	Down	SNORD35A (RPL13A)	RMS-Illumina	[44]
	SNORA23 depletion/overexpression	Up/down	SNORD35B (RPS11)	RTL-P	[48]
	AES depletion	Down		RTL-P	[55]
	ß-thalassemic patients vs. healthy donor	Up		RTL-P	[69]
28S-Gm4593	FBL depletion	Down	SNORD78	RMS-Illumina	[44]
	ZFAS1 depletion/overexpression	Up/down	(GAS5)	RTL-P/DBPST	[47]
	Cell lines, between breast cancer patients	Up and down		RMS-Illumina	[71]
	DLBCL patients vs. healthy donor, brain, liver and skeletal muscle	Up in DLBCL, Up in brain and liver		RMS-Ion Torrent	[70]

¹ Based on Biotoul database; ² RMS = RiboMeth-Seq.