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. 2021 Aug 5;13(16):3953. doi: 10.3390/cancers13163953

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Illustration of functional follow-up analysis of non-coding low penetrance common risk variants. (a) Integration of genotype and epigenomic data to identify the candidate regulatory targets of risk variants; (b) Integrative analysis of the correlation between genotype to gene expression paired with gene-regulatroy element interaction, identifies putative candidate susceptibility genes; and (c) genome editing, multiomics, and cell biology assays are utilized to functionally evaluate noncoding DNA elements and their potential target genes to uncover their role in neoplastic development.