Figure 3.

Müller cells exhibit GFAP upregulation/hypertrophy in the Q344X rhodopsin knock-in mouse retina. WT (A–D, I–L, Q–T) and Q344X (E–H, M–P, U–X) mouse retinal sections at 6, 15, and 24 weeks of age were immunolabeled for GFAP (red), GS (green) and rhodopsin (blue). Nuclei were labeled with DAPI (white). ROS/IS, rod outer segments/ inner segments; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bars = 20 µm.