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. 2021 Aug 9;9(8):980. doi: 10.3390/biomedicines9080980

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Glucocorticoid receptor and HSD11B2 enzyme gene expression. RT-qPCR of NR3C1 (A) and HSD11B2 (B) in SGHPL-4 cells treated with continuous or intermittent exposure to cortisol (100, 250, 500, 1000 nM) and vehicle (0 nM) in the medium. Data were compared by two-way ANOVA with Tukey multiple comparisons test. Interaction between (continuous or intermittent) exposure to cortisol and cortisol dose was found for NR3C1 (p < 0.0001). Data are presented as mean ± SEM. ** p < 0.01; **** p < 0.0001; for continuous exposure: b, p < 0.05 and a, p < 0.0001 vs. control. NR3C1, Glucocorticoid receptor; HSD11B2, 11-hydroxysteroid dehydrogenase type 2. Cell treatment was repeated at least three times.