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. 2021 Aug 9;9(8):980. doi: 10.3390/biomedicines9080980

Figure 5.

Figure 5

Chemokine gene expression. RT-qPCR of CXCL12 (A) and CXCR4 (B) in SGHPL-4 cells treated with continuous or intermittent exposure to cortisol (100, 250, 500, 1000 nM) and vehicle (0 nM) in the medium. Data were compared by two-way ANOVA with Tukey multiple comparisons test. Interaction between (continuous or intermittent) exposure to cortisol and cortisol dose was found for CXCL12 (p = 0.0027). Data are presented as mean ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; for continuous exposure: a, p < 0.0001 vs. control. CXCL12 (SDF-1), C-X-C motif chemokine ligand 12 (Stromal cell-derived factor 1); CXCR4, C-X-C chemokine receptor type 4. Cell treatment was repeated at least three times.