Table 4.
Multiple logistic regression model developed on data from the Discovery cohort and subsequently applied to data from the Validation cohort. The model included data on 101 and 95 participants, respectively, from the Discovery and Validation cohorts. * Statistically significant impact.
| Discovery Cohort | Validation Cohort | |||||
|---|---|---|---|---|---|---|
| Cases (n = 67) |
Controls (n = 34) |
Cases (n = 50) |
Controls (n = 45) |
|||
| Variables | OR (95% CI) | OR (95% CI) | p-Value | OR (95% CI) | OR (95% CI) | p-Value |
| Age, years | - | - | - | - | - | - |
| Crude OR | 1 (ref) | 1.06 (1.02–1.11) | 0.002 * | 1 (ref) | 1.08 (1.03–1.13) | 0.001 * |
| Adjusted OR | 1 (ref) | 1.06 (1.01–1.11) | 0.023 * | 1 (ref) | 1.07 (1.01–1.14) | 0.020 * |
| Smoking status, ever | - | - | - | - | - | - |
| Percentage ever smoked | 89.6% | 82.4% | 0.307 | 96.0% | 71.1% | 0.001 * |
| Crude OR | 1 (ref) | 1.84 (0.56–5.97) | 0.312 | 1 (ref) | 9.75 (2.06–46.14) | 0.004 * |
| Adjusted OR | 1 (ref) | 1.07 (0.24–4.74) | 0.928 | 1 (ref) | 5.20 (0.82–32.95) | 0.080 |
| HOXA9 status | - | - | - | - | - | - |
| Percentage HOXA9+ | 68.7% | 11.8% | <0.001 * | 80.0% | 24.4% | <0.001 * |
| Crude OR | 1 (ref) | 15.80 (5.30–47.06) | <0.001 * | 1 (ref) | 12.36 (4.68–32.64) | <0.001 * |
| Adjusted OR | 1 (ref) | 14.27 (4.62–44.06) | <0.001 * | 1 (ref) | 11.95 (4.11–34.75) | <0.001 * |