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Kynurenine monooxygenase in GBM tissue. (A) KMO mRNA copy number in tissue samples: patients diagnosed with a neurological disease (control, n = 6) versus patients diagnosed with grade II to IV astrocytoma (glioma, n = 9). (B) Determination of KMO activity by quantification of 3-HK levels after 2 h incubation of the same samples used for KMO expression. Data are shown with the median (horizontal line); * p < 0.05 based on the Mann–Whitney test.
