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. 2021 Aug 23;13(16):4238. doi: 10.3390/cancers13164238

Figure 4.

Figure 4

HGF rescues the reduction of tumorsphere formation by Cfd-KO mADSCs. (A) Profiling of adipokines secreted from WT- and Cfd-KO mADSCs. Culture medium of mADSCs was analyzed using cytokine arrays. The intensity of the spot for Cfd in WT mADSCs was set at 1.0. (B) Reduction of the HGF mRNA levels in the Cfd-KO mADSCs. The addition of Cfd in the culture medium (Cfd, 9.5 μg/mL) upregulated the expression level of Cfd mRNA in the Cfd-KO mADSCs. * p < 0.05. (C) HGF rescued the reduced ability of Cfd-KO ADSCs to induce sphere formation of breast cancer PDX cells. HGF (50 ng/mL) was added to the culture medium. The number of PDX tumorspheres (>100 μm in diameter) were presented. Scale bar, 100 μm. * p < 0.05.