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Overview of the TFAM-DNA complex. (a) The domain structure of the mature form of human TFAM without the mitochondrial targeting sequence (amino acid 43–246). (b) The crystal structure of human TFAM-DNA containing the light strand promoter (LSP) sequence (PBD: 3TQ6). Key DNA-intercalating residues, L58 and L182, are highlighted in sticks.
