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. 2021 Aug 26;19:368. doi: 10.1186/s12967-021-03043-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Identification of hub genes involved in LUAD and LUSC carcinogenesis and development. a, b Using the transcriptome data of LUAD (a n = 525) and LUSC (b n = 501) in the TCGA database, gene co-expression network analysis was performed to identify 5 overlapping hub genes from the aforementioned 21 overlapping genes: RAD51, CDK1, CCNB2, CDC25A, and GTSE1. c, d Univariate prognostic analysis of the aforementioned 21 genes in LUAD (c) and LUSC (d)