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. 2021 Aug 4;9(8):956. doi: 10.3390/biomedicines9080956

Figure 2.

Figure 2

Schematic representation of IL-6/JAK/STAT3 pathway: IL-6 family members recognize their cognate transmembrane receptors and transmembrane proteins associated with the receptors trigger the activation of JAKs. Activated JAKs phosphorylate Y705 of STAT3 and pSTAT3 Y705 migrates to the nucleus. In the nucleus, STAT3 can be acetylated by p300/CBP and methylated by SET9 or by EZH2. HDAC and LSD1 inhibit AcSTAT3 and MeSTAT3, respectively. The Ras/Raf/MEK/ERK pathway determines S727 phosphorylation. Y705 and S727 are both required for mitochondrial functions of STAT3. Alternatively, unphosphorylated STAT3 (U-STAT3) can also regulate specific nuclear targets. Created with BioRender.com.