Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic diagram summarizes the mechanisms of S1P-induced EPC angiogenesis during RA pathogenesis. S1P induces VEGF expression in osteoblasts by suppressing miR-16-5p expression via the S1P1 and S1P3 receptors, and the c-Src and FAK signaling pathways, and promotes EPC angiogenesis in RA.
