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Incidence of breast cancer and hypothyroidism as a function of the polygenic risk score (PRS) percentile. At a high PRS, the likelihood of incidence increases nonlinearly, and at a low PRS, the likelihood decreases nonlinearly. The red curve indicates the theoretical, modeling case, and control populations with normal distributions that were shifted in the mean PRS. The blue data points were calculated using individuals (not used in training) binned by the PRSs. Reproduced from [5].
