Table 2.
P-ANCA-related antigenic specificities in the various P-ANCA-positive autoimmune disease patients studied.
| Autoimmune Diseases | Antigens Recognized by P-ANCA Positive Sera (No Positive) | ||||||
|---|---|---|---|---|---|---|---|
| MPO | Elastase | Cathepsin G | BPI | Lactoferrin | MPO/Lactoferrin | ||
| Vasculitides | MPA (n = 18) | 11 | 0 | 0 | 0 | 0 | 0 |
| BD (n = 2) | 1 | 0 | 0 | 0 | 0 | 0 | |
| Aortitis (n = 1) | 0 | 0 | 0 | 0 | 0 | 0 | |
| HSP (n = 2) | 0 | 0 | 0 | 0 | 0 | 0 | |
| CV (n = 1) | 0 | 0 | 0 | 0 | 1/1 (100) | 0 | |
| SLE (n = 28) | 1 | 0 | 0 | 0 | 1/28 (3.6) | 1/28 (3.6) | |
| APS (n = 5) | 1 | 0 | 0 | 0 | 0 | 0 | |
| SS (n = 7) | 0 | 1 | 0 | 0 | 0 | 0 | |
| RA (n = 3) | 1 | 0 | 0 | 0 | 0 | 0 | |
| SSCL (n = 2) | 1 | 0 | 0 | 0 | 0 | 0 | |
| Sarcoidosis (n = 1) | 0 | 0 | 0 | 0 | 0 | 0 | |
| Hashimoto (n = 13) | 0 | 0 | 0 | 0 | 0 | 0 | |
P-ANCA: perinuclear antineutrophil cytoplasmic antibodies, MPO: myeloperoxidase, BPI: bactericidal/permeability-increasing protein, MPA: microscopic polyangiitis, BD: Behcet’s disease, HSP: Henoch–Schonlein purpura, CV: cryoglobulinemic vasculitis, SLE: systemic lupus erythematosus, APS: antiphospholipid syndrome, SS: Sjögren’s syndrome, RA: rheumatoid arthritis, SSCL: systemic sclerosis. Positive values are highlighted by bold type letters.