Table 2.
Subgroup analysis.
| Subgroups | No. of Studies | MD in Average vBMD | 95% CI | TSA Adjusted 95% CI | I2 (%) |
|---|---|---|---|---|---|
| Overall | 5 | −14.90 | −22.90 to −6.89 * | −23.77 to −6.03 * | 41 |
| Geographic location | |||||
| Europe | 3 | −12.82 | −24.64 to −1.00 * | −29.97 to 4.33 | 67 |
| Asia | 2 | −20.09 | −33.25 to −6.93 * | −34.65 to −5.53 * | 0 |
| Anatomical site | |||||
| Distal radius | 3 | −19.28 | −26.54 to −12.03 * | −26.69 to −11.88 * | 0 |
| Metacarpal head | 2 | −11.68 | −28.26 to 4.90 | −79.36 to 56.00 | 69 |
* p < 0.05, indicated statistically significant. CI, confidence interval; MD, mean difference; No., number; TSA, trial sequential analysis; vBMD, volumetric bone mineral density.