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. 2021 Aug 20;9(8):1053. doi: 10.3390/biomedicines9081053

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Part 1 of the left ventricular cardiac function assessment by invasive hemodynamic analysis performed 22 weeks after creation of the aorto-caval fistula (ACF) and 20 weeks after initiation of treatment in sham-operated transgene-negative Hannover Sprague-Dawley (HanSD), sham-operated heterozygous Ren-2 transgenic rats (TGR) and TGR rats with ACF treated with angiotensin-converting enzyme inhibitor (ACEi) alone or with 14,15-epoxyeicosatrienoic acid analog (EET-A) alone or with the combination of EET-A and ACEi. Left ventricle peak pressure (A), left ventricle end-diastolic pressure (B), left ventricle end-diastolic volume (C), maximum rates of pressure rise (+dP/dt)_max (D), maximum rates of pressure fall (-dP/dt)_max (E), relaxation constant tau (F). * p < 0.05 for sham-operated TGR versus sham-operated HanSD rats. ^# p < 0.05 for ACF TGR versus sham-operated TGR.