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. 2021 Aug 20;9(8):1053. doi: 10.3390/biomedicines9081053

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Part 2 of the left ventricular cardiac function assessment by invasive hemodynamic analysis performed 22 weeks after creation of the aorto-caval fistula (ACF) and 20 weeks after initiation of treatment in sham-operated transgene-negative Hannover Sprague-Dawley (HanSD), sham-operated heterozygous Ren-2 transgenic rats (TGR) and TGR rats with ACF, untreated or treated either with angiotensin-converting enzyme inhibitor (ACEi) alone or with 14,15-epoxyeicosatrienoic acid analog (EET-A) alone or with the combination of EET-A and ACEi. End-systolic pressure-volume relationship (ESPVR) (A), end-diastolic pressure-volume relationship (EDPVR) (B), preload recruitable stroke work (C), total peripheral resistance (D), total power output (E), left ventricular wall stress (F). * p < 0.05 sham-operated TGR versus sham-operated HanSD rats. ^# p < 0.05 for ACF TGR versus sham-operated TGR. ^@ p < 0.05 versus other ACF TGR.