Table 4.
Body and organ weights 22 weeks after creation of the aorto-caval fistula (ACF) or sham-operation and after 20-weeks’ treatment with 14,15-epoxyeicosatrienoic acids analog (EET-A) and angiotensin-converting enzyme inhibitor (ACEi), alone or combined with EET-A.
| Group | |||||
|---|---|---|---|---|---|
| HanSD | TGR | ACF TGR | ACF TGR | ACF TGR | |
| +water | +water | +ACEi | +EET-A | +EET-A + ACEi | |
| Body Weight (g) | 630 ± 10 | 633 ± 9 | 689 ± 8 # | 701 ± 19 | 608 ± 18 @ |
| Tibia length (mm) | 43.8 ± 0.2 | 43.7 ± 0.3 | 44.1 ± 0.4 | 44.2 ± 0.4 | 44.1 ± 0.4 |
| Whole heart weight (mg)/tibia length (mm) | 33.67 ± 0.58 | 46.69 ± 0.79 * | 65.09 ± 1.12 # | 66.12 ± 1.22 # | 55.01 ± 1.09 @ |
| LV weight (mg)/tibia length (mm) | 26.94 ± 0.23 | 34.55 ± 0.89 * | 39.22 ± 0.27 # | 40.27 ± 0.29 # | 33.33 ± 0.21 @ |
| RV weight (mg)/tibia length (mm) | 7.47 ± 0.21 | 7.57 ± 0.18 | 15.87 ± 0.35 # | 15.77 ± 0.33 # | 11.36 ± 0.22 @ |
| RV weight (mg)/LV weight (mg) | 0.277 ± 0.03 | 0.219 ± 0.03 | 0.405 ± 0.04 # | 0.392 ± 0.03 # | 0.341 ± 0.03 @ |
| Lung weight (mg)/tibia length (mg) | 49.77 ± 1.18 | 48.06 ±1.23 | 61.91 ± 1.51 # | 66.97 ± 1.78 # | 51.29 ± 0.98 @ |
| Kidney weight (mg)/tibia length (mg) | 42.69 ± 0.99 | 42.56 ± 1.17 | 39.01 ± 1.23 | 40.27 ± 1.16 | 39.23 ± 1.25 |
| Liver weight (mg)/tibia length (mg) | 458 ± 19 | 440 ± 23 | 444 ± 27 | 437 ± 25 | 447 ± 28 |
Values are the means ± SEM. LV, left ventricle; RV, right ventricle; * p < 0.05 vs. sham-operated HanSD rats; # p < 0.05 vs. TGR + water; @ p < 0.05 vs. ACF TGR + ACEi and vs. ACF TGR + EET-A.