Table 2.
Clinical trials currently evaluating immunotherapies in CCA. List of clinical trials involving combination immune checkpoint inhibitors, adoptive cell transfer, and other innovative immunotherapies in CCA. Source: clinicaltrials.gov (28 July 2021). CCA, cholangiocarcinoma; TIL, tumor-infiltrating lymphocyte; CAR-T cell, chimeric antigen receptor T cell; CIK, cytokine-induced killer.
| Trial Identifier | Phase | Status | Immunotherapy | Co-Treatments | Participants |
|---|---|---|---|---|---|
| NCT02834013 | II | Recruiting | Combination immune checkpoint inhibitors (CTLA-4 with PD-1) | N/A | 818 |
| NCT03473574 | II | Active, not recruiting | Combination immune checkpoint inhibitors (CTLA-4 with PD-1) | Gemcitabine, Cisplatin | 128 |
| NCT02821754 | II | Recruiting | Combination immune checkpoint inhibitors (CTLA-4 with PD-1) | Transarterial catheter chemoembolization, radiofrequency ablation, cryoablation | 90 |
| NCT04634058 | II | Not yet recruiting | Combination immune checkpoint inhibitors (CTLA-4 with PD-1) | N/A | 40 |
| NCT03058289 | I/II | Recruiting | Combination immune checkpoint inhibitors (CTLA-4 with PD-1) | Novel chemotherapy (INT230-6) | 180 |
| NCT03849469 | I | Recruiting | Bispecific antibody against CTLA-4 and LAG-3, combination bispecific antibody and immune checkpoint inhibitor (PD-1) | N/A | 242 |
| NCT04641871 | I | Active, not recruiting | Combination immune checkpoint inhibitors (PD-1 with LAG-3 or TIM-3) | N/A | 200 |
| NCT04672434 | I | Recruiting | Combination immune checkpoint inhibitors (PD-1 with CD73) | N/A | 100 |
| NCT03872947 | I | Recruiting | Monoclonal antibody against undisclosed tumor-associated antigen with immune checkpoint inhibitors (PD-1 or CTLA-4) | Imiquimod Cream, Irinotecan, Leucovorin, 5-FU, Gemcitabine, Cisplatin, Carboplatin, Ramucirumab, Paclitaxel | 75 |
| NCT03801083 | II | Recruiting | TIL adoptive cell transfer | N/A | 59 |
| NCT03633773 | I/II | Recruiting | MUC-1 CAR-T cell | N/A | 9 |
| NCT04951141 | I | Recruiting | GPC3 CAR-T cells | N/A | 10 |
| NCT01868490 | I/II | Recruiting | CIK adoptive cell transfer | N/A | 13 |
| NCT03942328 | I | Recruiting | Autologous dendritic cells | External Beam Radiation Therapy, Pneumococcal 13-valent Conjugate Vaccine | 26 |
| NCT04853017 | I/II | Recruiting | Peptide vaccine against KRAS mutations | N/A | 159 |