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. 2021 Aug 13;22(4):1175. doi: 10.3892/etm.2021.10607

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Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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PF alleviates HG-induced filtration barrier injury via the AMPK pathway. (A) Permeability of GEnCs to FITC-dextran. (B) Expression levels of Sdc-1 in the cell culture supernatant. (C) Western blot analysis of Hpa-1, ZO-1 and occludin-1. Densitometry analysis of (D) Hpa-1, (E) ZO-1 and (F) occludin-1. Data are presented as the mean ± standard deviation of three repeats. ^*P<0.05, ^**P<0.01, ^***P<0.001 vs. control. ^#P<0.05, ^##P<0.01, ^###P<0.001 vs. HG; ^$P<0.05, ^$$P<0.01 vs. HG + PF or siCon + HG + PF. PF, piperazine ferulate; HG, high glucose; AMPK, adenosine monophosphate-activated protein kinase; GEnCs, glomerular endothelial cells; FITC, fluorescein isothiocyanate; Sdc-1, syndecan-1; Hpa-1, heparanase-1; ZO-1, Zonula occludens-1; si, small interfering; NC, negative control.