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Profiling of genetic mutations and MICs for BDQ-resistant MTB isolates
| Locus | Mutation | No. of isolates with corresponding MIC (μg/ml) | Total (%) | ||
|---|---|---|---|---|---|
| 0.25 | 0.5 | 1 | |||
| Rv0678 | Ala86Val | 1 | 1 (10.0) | ||
| Ile108Thr | 1 | 1 (10.0) | |||
| Arg109Pro | 1 | 1 (10.0) | |||
| Deletion A in codon 110 | 1 | 1 (10.0) | |||
| Wild-type | 4 | 1 | 1 | 6 (60.0) | |
| Total | 5 | 4 | 1 | 10 (100.0) | |
MIC, minimum inhibitory concentration; BDQ, bedaquiline; MTB, Mycobacterium tuberculosis
