Table 5.

Univariate and multivariate analyses of prognostic markers for overall survival in ESCC

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Nuclear NRF2 expression			0.005			0.002
High vs. low or no	1.802	1.191–2.729		1.908	1.256–2.899
SLC7A11 expression			0.004			0.010
Positive vs. negative	1.858	1.220–2.829		1.767	1.146–2.725
Sex			0.019			0.022
Male vs. Female	0.598	0.389–0.919		0.6	0.389–0.927
Age (years)			0.067
≤ 60 vs. > 60	1.583	0.969–2.584
Alcohol abuse			0.200
Yes vs. No	1.318	0.864–2.011
Smoking			0.444
Yes vs. No	1.172	0.781–1.758
Location			0.002			0.002
Upper vs. Middle/Lower	1.898	1.268–2.839		1.908	1.256–2.899
Length (cm)			0.038
≤ 4 vs. > 4	1.566	1.025–2.394
T stage			0.007
T1–2 vs. T3–4	1.542	1.126–2.112
Lymph node metastasis			0.001
N0–1 vs. N2–3	1.741	1.243–2.437
Distant metastasis			0.004
M0 vs. M1	2.404	1.321–4.375
TNM stage			0.001
I–II vs. III–IV	1.634	1.220–2.188
Treatment strategy			0.606
CRT vs. RT	0.888	0.566–1.394

HR: Hazard ratio; CI: confidence interval

*p < 0.05