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. 2021 Jul 23;10(8):1873. doi: 10.3390/cells10081873

Figure 4.

Figure 4

The gene expression pattern of TGF-β and BMP components is different in brown bear muscle resistant to atrophy during hibernation compared to atrophied muscles of the unloaded mouse. Genes expression level in vastus lateralis muscle of active and hibernating brown bears (n = 6 bears/season, the same individuals were sampled and analyzed in summer and winter, log2FC Winter/Summer, dotted white bars) and in soleus muscle of control and unloaded mice (n = 4 mice per condition, log2FC Unloaded/Control, gray bars). The depicted genes were categorized as TGF-β and BMP (a) ligands, (b) receptors, and (c) intracellular actors. Data are expressed as log2FC ± lfcSE. Statistical significance is shown (* padj < |0.05|; ** padj < |0.01|; *** padj < |0.001|).