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. 2021 Jul 23;10(8):1873. doi: 10.3390/cells10081873

Figure 5.

Figure 5

The gene expression pattern of muscle E3s/DUB enzymes involved in TGF-β and BMP pathway regulation differed in the atrophy-resistant brown bear muscle during hibernation compared to the atrophied muscle of the unloaded mouse. Genes expression level (a) in vastus lateralis muscle of active and hibernating brown bears (n = 6 bears/season, the same individuals were sampled and analyzed in summer and winter, log2FC Winter/Summer, dotted white bars), and (b) in soleus muscle of control and unloaded mice (n = 4 mice per condition, log2FC Unloaded/Control, gray bars). Data are expressed as log2FC ± lfcSE. Statistical significance is shown (* padj < |0.05|; ** padj < |0.01|; *** padj < |0.001|).