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Schematic illustrating loss of developmental homeostasis in the choroid plexus and ependyma in the context of hydrocephalus. In the perinatal brain, dysregulation of the ventricular microenvironment encompasses loss of ependymal motile cilia, choroid plexus injury, and changes in the neurogenic niche. These changes are concomitant with choroid plexus cell death and ependymal cell death. (Ctx = cortex, CC = corpus callosum).
