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Comparison between viral and non-viral vectors.
| Vectors | |||||
|---|---|---|---|---|---|
| Viral | Non-Viral | ||||
| AD | HSV | RT | Cationic Liposomes | Polymers (PEI, PAMAM) |
|
| Diameter (nm) | 150–200 | 100–300 | 100 | 20–200 | 50–250 |
| Genetic Payload | dsDNA | dsDNA | RNA | dsDNA/RNA | dsDNA/RNA |
| Transduction Efficiency | High | Very High | Medium | High | High |
| Immunogenicity | Very High | Very High | Medium | None | None |
| Mutagenesis Risk | None | None | Yes | None | None |
AD: Adenovirus; HSV: Herpes Simplex Virus; PAMAM: Poly-Amidoamine Polymer; PEI: Polyethylenimine; RT: Retrovirus.
