Table 3.
Classification of Gene Therapies for High-Grade Gliomas.
| Gene Therapies | ||
|---|---|---|
| Oncolytic Virotherapy | Oncolytic viruses | oHSV |
| CRAd | ||
| MV | ||
| PVS-RIPO | ||
| Suicide Gene Therapy | Suicide Genes | TK |
| CD | ||
| PNP | ||
| Tumor Suppressor Gene Therapy | Tumor Suppressor Genes | p53 |
| p16 | ||
| PTEN | ||
| Immunomodulatory Gene Therapy | Immunomodulatory Genes | IFNβ/γ |
| IL-4, IL-12 | ||
| Gene Target Therapy | Target Genes | EGFRvIII |
| VEGF | ||
CD: Cytosine Deaminase; CRAd: Conditionally Replicating Adenovirus; EGFRvIII: Epidermal Growth Factor Receptor Variant vIII; oHSV: Oncolytic Herpes Simplex Virus; IFN: Human Interferon; IL: Interleukine; MV: Measles Paramyxovirus; PNP: Purine Nucleoside Phosphorylase; PTEN: Phosphatase and Tensin Homologue; PVS-RIPO: Recombinant Nonpathogenic Polio-Rhinovirus; TK: Thymidine Kinase; VEGF: Vascular Endothelial Growth Factor.