Table 1A.
Characteristics of North American childhood cancer survivor cohorts
| Characteristics | CCSS | SJLIFE | CAYACS |
|---|---|---|---|
| Country or province | USA and Canada | USA | British Columbia, Canada |
| Year of establishment | 1994 | 2007 | 2005 |
| Period of cancer diagnosis | 1970–1999 | 1962–2012 | 1970–2010 |
| Cohort size | 37,593 (25,664 active participants) | 8,245 (6,004 active participants) | 8,735 |
| Survival at entry | ≥5 years | ≥5 years | 0 years |
| Age at cancer diagnosis (years) | 0–20 | 0–24 | 0–24 |
| Type of cancer | Leukemia, CNS, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, neuroblastoma, soft tissue sarcoma, Wilms, bone tumors | All types | All types |
| Study design | Hospital-based retrospective cohort with prospective follow-up | Hospital-based retrospective cohort with prospective follow-up | Retrospective population-based cohort with prospective follow-up |
| Obtained information | Surveys, medical records | Clinical assessments, surveys, medical records | Registries, administrative databases, medical records |
| Comparison population | Siblings, general population | Frequency matched community controls, general population | Random sample from the general population of British Columbia |
| Therapeutic exposures | Yes (>90%) | Yes (100%) | Yes |
| Collection of germline DNA | For some (<60%) | Yes (>95%) | NA |