Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 31;10(8):1955. doi: 10.3390/cells10081955

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Germline-encoded Ly49H mediate viral antigen-specific recognition. During mouse cytomegalovirus (MCMV) infection, NK cells expressing the Ly49H receptor recognize MCMV-infected cells via the MCMV-derived glycoprotein m157. Stimulation of the Ly49H leads to the activation of the DAP12-mediated signaling pathway, driving NK cell degranulation and secretion of perforins and granzymes. DNAX accessory molecule-1 (DNAM-1) and pro-inflammatory cytokines (IFN-α/β and IL-1) partially drive the clonal-like expansion of NK cells. Inhibitory KIR2DL2/3 in humans and Ly49A/C/G2 in mice can block the membrane proximal activation events upon the recognition of MHC class I.