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. 2021 Aug 4;22(16):8359. doi: 10.3390/ijms22168359

Figure 3.

Figure 3

BK current activation by Chl-T oxidation in IGR39 cells. (a) Currents in a typical IGR39 cell elicited in STD solution (left) and after addition of 0.5 mM Chl-T (middle). Chl-T-evoked currents were blocked by 30 mM TEA (right traces). Average block at 100 mV: 81.9 ± 3.7% (p = 0.017, n = 8). (b) Representative currents recorded from another IGR39 cell. The potassium current, stimulated by oxidation, was blocked at positive voltages by 1 µM paxilline (right panel). Average block at 100 mV: 79.0 ± 2.5% (p = 0.0062, n = 6). (c) Average current density–voltage relationships for IGR39 cells treated with Chl-T and 30 mM TEA (top panel) and Chl-T and 1 µM paxilline (bottom). Data are expressed as mean ± SEM from 6 experiments each.