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. 2021 Aug 4;22(16):8359. doi: 10.3390/ijms22168359

Figure 8.

Figure 8

Activation of heterologously expressed TRMP2 by Chl-T. (a) Time course of currents elicited in an HEK-null cell during the addition of 0.5 mM ChlT in STD solution. (b,c) Time course of currents recorded in two representative transfected HEK293 cells during the application of 0.5 mM ChlT and subsequent addition of 20 µM ACA (b) or 30 µM clotrimazole (c). Normalized current increase at 100 mV: 2.18 ± 0.39, p = 0.007, n = 11. Average ACA block at 100 mV: 55.89 ± 1.92% (p = 0.00006, n = 4), and average clotrimazole block at 100 mV: 29.48 ± 1.97 (p = 0.0007, n = 4).