Figure 5.

PLA increases muscle fiber size and attenuates muscle fat infiltration in Ctns^−/− mice. Representative photomicrographs of the gastrocnemius with H&E staining (A–D). Average gastrocnemius cross-sectional area was measured (E). Visualization of the quantification of fatty infiltration by Oil Red O analysis in the gastrocnemius muscle (F–J). Final results were expressed in arbitrary units, with one unit being the mean staining intensity in vehicle-treated WT mice. In addition, results of PLA-treated Ctns^−/− mice were compared to vehicle-treated Ctns^−/− mice and specific p-values are shown above the bar. ** p < 0.01, *** p < 0.001.