Table 1.

Serum and blood chemistry of mice. Twelve-month-old Ctns^−/− and WT mice were treated with PLA (7 mg/kg/day, IP) or vehicle (normal saline) for 28 days. Four groups of mice were included: WT + Vehicle, WT + PLA, Ctns^−/− + Vehicle and Ctns^−/− + PLA. Ctns^−/− + Vehicle mice were fed ad libitum whereas WT + Vehicle, WT + PLA and Ctns^−/− + PLA mice were pair-fed to that of Ctns^−/− + Vehicle mice. Data are expressed as mean ± SEM. Results of Ctns^−/− + Vehicle mice were compared to those of WT + Vehicle mice whereas results of Ctns^−/− + PLA mice were compared to those of WT + PLA mice. * p < 0.05.

	WT + Vehicle (n = 9)	WT + PLA (n = 9)	Ctns−/− + Vehicle (n = 12)	Ctns−/− + PLA (n = 12)
BUN (mg/dL)	29.5 ± 4.6	32.4 ± 3.1	59.8 ± 6.7 *	74.5 ± 9.4 *
Creatinine (mg/dL)	0.09 ± 0.02	0.12 ± 0.04	0.19 ± 0.02 *	0.21 ± 0.04 *
Bicarbonate (mmol/L)	28.2 ± 2.2	27.6 ± 2.1	27.3 ± 1.8	27.3 ± 1.1
Leptin (ng/mL)	2.6 ± 0.3	2.8 ± 0.5	4.6 ± 0.4 *	5.2 ± 0.3 *