Figure 7.

Cotreatment regimen (Experiment 3) (N = 8–10 in each group). Paclitaxel impaired neurogenesis, especially the neuroblast production in the dentate gyrus. The neuroblasts were marked as DCX-immunopositive cells. The BrdU- and Ki-67-immunopositive cell counts tended to be reduced in the paclitaxel group, but the differences were not statistically significant compared with the control group. The memantine pretreatment enhanced neurogenesis by increasing the Dcx- and BrdU-immunoreactive cell counts and restored neurogenesis by increasing the Dcx-immunopositive cell counts in the memantine + paclitaxel group compared with the paclitaxel group, but the Ki-67-immunopositive cell counts were similar between the groups. * p < 0.05, ** p < 0.01, and *** p < 0.001.