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. 2021 Aug 19;13(16):4177. doi: 10.3390/cancers13164177

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cotreatment regimen (Experiment 3) (a) Body weights of the mice in the four groups after treatment. The data are presented as the mean ± SE of the mean. (b) The memantine cotreatment protocol significantly improved the spatial memory in the memantine + paclitaxel group. * Compared with the control group. # Compared with the paclitaxel group. (c) The OFT tracked the paths of the four groups. (d) Paclitaxel still impaired the locomotor activity in the paclitaxel group. However, the paclitaxel-treated mice cotreated with memantine exhibited a reversal of anxiety. The FST showed no prominent depression-like behavior in the memantine + paclitaxel group. Body weight: N = 5 in each group, MWM: N = 10 in each group, OFT: N = 10–15 in each group, and FST: N = 9–10 in each group. * p < 0.05, ** p < 0.01, and *** p < 0.001.