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. 2021 Jul 30;10(8):1943. doi: 10.3390/cells10081943

Figure 2.

Figure 2

(a) Relative expression of common reactive astrocyte genes (GFAP and S100B) in the spinal cord segments (site of the injury, cranially and caudally) one and two weeks after Th9 compression. Gene expression of both markers was strongly up-regulated mainly at the injury site and adjacent cranial segments two weeks after SCI. (b) Expression of genes (C3, TNF-α and C1q) induced by neurotoxic A1 reactive astrocytes one and two weeks after Th9 compression. Data are mean values of five experiments ±SD. The mRNA levels for each marker were normalized to the mRNA levels of 18sRNA and expressed as ∆∆Ct values relative to controls. Results were statistically evaluated using unpaired t-test; * p ˂ 0.05; *** p ˂ 0.001; **** p ˂ 0.0001. GFAP—Glial fibrillary acidic protein; S100B—Calcium-binding protein B; C—Complement 3; SCI—spinal cord injury; TNF-α—tumor necrosis factor-α; C1q—Complement component 1q.