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. 2021 Aug 24;12(8):646–655. doi: 10.5306/wjco.v12.i8.646

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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TRIM25 is an E3-ligase common for interferon-stimulated gene 15 and ubiquitin proteins. A: The ISGylation system; B: The Ubiquitination system. The ISGylation system and the ubiquitination system are similar, however, the ubiquitination system has more than 600 E3 ligases and the ISGyaltion system has three E3 ligases. Interestingly, both systems have in common the E3 ligase tripartite motif containing 25. ISG15: Interferon-stimulated gene 15; DUBs: Ubiquitin-proteasome system; Ub: Ubiquitin; USP18: Ubiquitin-specific protease 18.