Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Aug 24;12(8):646–655. doi: 10.5306/wjco.v12.i8.646

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

PMC Copyright notice

Structure of TRIM25. A: Crystal structure of the human TRIM25 coiled-coil and PRYSPRY domains. (DNA sequence retrieved from NCBI. Gene, https://www.ncbi.nlm.nih.gov/gene/7706#gene-expression 21/01/21, and 3D model created with Swiss Model: https://swissmodel.expasy.org/); B: Schematic representation of TRIM25, including the conserved RING, B boxes (B1 and B2), the coiled-coil domain and the C-terminal variable domain (CTD) PRY-SPRY; C: RING and CTD domains bind to the ubiquitin-loaded E2 and the substrate, respectively. Consequently, both molecules get closer, therefore favoring substrate ubiquitination.