Table 1.
Demographic and laboratory data of patients and controls
| Parameter | ITP patients (N = 60) |
Control (N = 50) |
P-value |
|---|---|---|---|
| Age (year) | 0.345 | ||
| Range | 1–12 | 1–14 | |
| Mean ± SD | 5·5 ± 3·2 | 6·8 ± 3·9 | |
| Sex | 0.254 | ||
| Male | 38 (63.3%) | 24 (48.0%) | |
| Female | 22 (36.7%) | 26 (52.0%) | |
| Weight centile (th) | 0.09 | ||
| Range | 75–90 | 75–80 | |
| Mean ± SD | 49.8 ± 20.8 | 47.8 ± 18.5 | |
| Length/Heigh centile (th) | 0.07 | ||
| Range | 50–75 | 50–75 | |
| Mean ± SD | 64.8 ± 11.6 | 61.24 ± 12.4 | |
| Residence | 0.234 | ||
| Rural | 32 (53.0%) | 28 (56.0%) | |
| Urban | 28 (47.0%) | 22 (44.0%) | |
| Hb (gm/dL) | < 0.001* | ||
| Range | 7–11.5 | 11–12.4 | |
| Mean ± SD | 9.1 ± 1.2 | 11.6 ± 0.4 | |
| WBCs × 109/L | 0.354 | ||
| Range | 4–13 | 4.8–13.6 | |
| Mean ± SD | 6.8 ± 2 | 7.3 ± 2.7 | |
| Platelets × 109/L | < 0.001* | ||
| Range | 9–67 | 218–461 | |
| Mean ± SD | 52.9 ± 25.6 | 280.3 ± 46.4 | |
| MPV, fl | 0.006* | ||
| Range | 9.4–11.4 | 7.7–8.9 | |
| Mean ± SD | 11.2 ± 1.6 | 7.9 ± 5 | |
| Th17 (%) | < 0.001* | ||
| Range | 1–3.9 | 0.3–1.9 | |
| Mean ± SD | 2.1 ± 0.9 | 1.1 ± 0.4 | |
| IL-23 (pg/mL) | < 0.001* | ||
| Range | 109.6–378.6 | 34.9–140.7 | |
| Mean ± SD | 215.4 ± 79 | 86.4 ± 32.7 | |
| IL-17A (pg/mL) | < 0.001* | ||
| Range | 40.7–369 | 31–191.9 | |
| Mean ± SD | 92.4 ± 39 | 42.7 ± 19 | |
N number, SD standard deviation, Hb hemoglobin, WBCs white blood cells, MPV mean platelets volume
*p-value < 0.05 = significant