Table 5.
MIC values of NE-incubated next generation peptides and parents against P. aeruginosa 27853 following NE incubation. MIC values of NE-incubated peptides against P. aeruginosa 27853 as determined by RDAs. Peptides were incubated with/without 500 nM NE for four hours prior to RDAs.
| Peptide | MIC (μM ± SEM) against P. aeruginosa 27853 | ||
|---|---|---|---|
| Peptide Alone | Peptide + NE | Fold Change in MIC | |
| Sn1b (n = 4) | 3.59 ± 2.13 | 7.31 ± 3.36 | 2.04 |
| Sn1bN (n = 2) | 5.32 ± 4.16 | 5.09 ± 4.31 | 0.957 |
| SnE1 (n = 4) | 3.25 ± 1.96 | 5.07 ± 3.85 | 1.56 |
| SnE1N (n = 3) | 4.28 ± 2.03 | 6.54 ± 3.87 | 1.53 |
| SnE1-F (n = 2) | 2.04 ± 0.315 | 4.84 ± 1.31 | 2.37 |