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. 2021 Aug 6;10(8):2010. doi: 10.3390/cells10082010

Figure 1.

Figure 1

Loss of HMGB1 in rods increases apoptosis of photoreceptor cells after retinal detachment (RD). (a) TUNEL Rod mice at RD 3 d. Nuclei were counterstained with 4′,6-diamidino-2-phenylindole (DAPI). Green: TUNEL positive cells, Blue: DAPI. Scale bar: 100 µm. GCL: ganglion cell layer, INL: inner nuclear layer, ONL: outer nuclear layer, RPE: retinal pigment epithelium. (b) Graph shows the quantification of TUNEL positive cells in the ONL in the attached and detached retinas from (a). Three non-continuous sections that cross the optic nerve head were used for the quantification of each eye. Each group contains five independent eyes. Data are plotted with mean ± s.d. * p < 0.05, **** p < 0.0001 (ANOVA).