Table 1.
Factors affecting Müller glia regeneration in mammals.
| Signalling Pathway/ Factor |
Function | Species Tested | Effect on Müller Glia Regeneration | References |
|---|---|---|---|---|
| Ascl1 | Transcription factor | Birds, rodents | Stimulates | [49,55,56] |
| BMP-SMAD | Signalling pathways activated by a secreted factor (BMP) when binding to a transcription factor (SMAD) | Rodents | Stimulates | [56] |
| EGF/EGFR | Signalling pathways activated by a secreted factor (EGF) when binding to its receptor (EGFR) | Rodents | Stimulates | [49,57,58] |
| Glutamate | Neurotransmitter | Rodents | Stimulates | [59] |
| FGF2-FGFR-MAPK | Secreted factor (FGF2) binding to its receptor (FGFR) to activate a signalling pathway (MAPK) | Birds, rodents | Stimulates | [57,65,66,67,68] |
| Delta-Notch | Signalling cascade activated by a transmembrane ligand (Delta) binding to its receptor | Birds, rodents | Stimulates | [20,49,65] |
| Pax6 | Transcription factor | Birds, rodents | Unknown | [49,69] |
| Insulin-IGF1-PI3K | Secreted factor (FGF2) binding to its receptor (FGFR) to activate a signalling pathway (MAPK) | Birds, rodents | Stimulates | [66,67,68] |
| SHH | Secreted factor | Rodents | Stimulates | [62,70] |
| TGF-B | Secreted factor | Rodents | Inhibits | [52,57,58] |
| Wnt/B-catenin | Signal transduction pathway | Rodents | Stimulates | [51,52,71,72] |