. 2021 Aug 5;13(16):3956. doi: 10.3390/cancers13163956

Table 3.

Standardized mortality ratios for death after 5 years for AYA cancer survivors by cancer site and ICD coded cause of death, diagnosed 1975–2012, SEER-9.

Primary Cancer Site	Data Shown in Cause of Death Columns	All Causes	Malignant Causes	All Non- Malignant Causes	Cardio/Cerebrovascular	Infections	Pulmonary	Renal	Liver and Cirrhosis	Pregnancy and Childbirth	Suicide	Accidents	Homicides and Legal Intervention	All Other Coded Causes
All cancers ¹	Obs	25,999	17,280	8378	2928	986	379	196	277	16	380	800	80	2336
All cancers ¹	SMR [95% CI]	2.93 [2.90, 2.97]	6.35 [6.26, 6.45]	1.37 [1.34, 1.40]	1.38 [1.33, 1.43]	1.97 [1.85, 2.10]	1.11 [1.00, 1.23]	1.85 [1.60, 2.13]	0.94 [0.83, 1.06]	3.13 [1.79, 5.08]	1.15 [1.04, 1.27]	1.02 [0.95, 1.09]	0.71 [0.56, 0.88]	1.55 [1.49, 1.62]
Breast, female	Obs	6357	5426	917	366	75	49	15	26	4	27	62	8	285
Breast, female	SMR [95% CI]	4.76 [4.65, 4.88]	10.96 [10.67, 11.26]	1.10 [1.03, 1.17]	1.22 [1.10, 1.36]	1.13 [0.89, 1.41]	0.74 [0.55, 0.98]	0.78 [0.44, 1.28]	0.76 [0.50, 1.11]	4.70 [1.28, 12.02]	1.09 [0.72, 1.59]	0.85 [0.65, 1.09]	0.93 [0.40, 1.83]	1.19 [1.05, 1.33]
Hodgkin lymphoma	Obs	2583	1368	1206	557	159	38	21	19	1	41	93	5	272
Hodgkin lymphoma	SMR [95% CI]	4.50 [4.33, 4.68]	9.35 [8.87, 9.86]	2.84 [2.68, 3.00]	4.26 [3.91, 4.63]	4.18 [3.56, 4.89]	2.43 [1.72, 3.33]	3.65 [2.26, 5.58]	0.90 [0.54, 1.41]	2.01 [0.05, 11.18]	1.30 [0.93, 1.76]	1.27 [1.02, 1.55]	0.38 [0.12, 0.89]	2.86 [2.53, 3.22]
Non-Hodgkin lymphoma	Obs	1454	846	602	157	180	19	13	13	0	23	50	8	139
Non-Hodgkin lymphoma	SMR [95% CI]	3.55 [3.37, 3.73]	7.66 [7.15, 8.20]	2.02 [1.86, 2.19]	1.54 [1.30, 1.80]	7.11 [6.11, 8.23]	1.46 [0.88, 2.28]	2.82 [1.50, 4.83]	0.87 [0.46, 1.49]	0.00 [0.00, 17.80]	1.22 [0.78, 1.84]	1.15 [0.85, 1.51]	1.06 [0.46, 2.09]	2.05 [1.73, 2.42]
Bone/soft tissue sarcoma ¹	Obs	1256	866	373	132	36	14	4	12	2	19	48	7	99
Bone/soft tissue sarcoma ¹	SMR [95% CI]	2.97 [2.81, 3.14]	7.37 [6.89, 7.88]	1.23 [1.11, 1.36]	1.27 [1.06, 1.51]	1.31 [0.92, 1.82]	1.00 [0.55, 1.67]	0.77 [0.21, 1.97]	0.86 [0.44, 1.50]	7.40 [0.90, 26.72]	1.09 [0.66, 1.71]	1.13 [0.84, 1.50]	0.84 [0.34, 1.73]	1.40 [1.14, 1.70]
Cervical/ uterine	Obs	1774	844	923	307	80	67	33	23	1	20	73	8	311
Cervical/ uterine	SMR [95% CI]	2.29 [2.19, 2.40]	2.96 [2.77, 3.17]	1.90 [1.78, 2.03]	1.78 [1.59, 2.00]	2.04 [1.62, 2.54]	1.80 [1.39, 2.28]	2.96 [2.04, 4.16]	1.15 [0.73, 1.73]	1.70 [0.04, 9.50]	1.31 [0.80, 2.03]	1.64 [1.29, 2.07]	1.40 [0.61, 2.76]	2.23 [1.99, 2.49]
Testicular germ cell	Obs	1384	571	801	265	93	18	15	48	-	70	98	11	183
Testicular germ cell	SMR [95% CI]	1.31 [1.24, 1.38]	2.29 [1.20, 2.48]	1.00 [0.93, 1.07]	0.96 [0.85, 1.09]	1.40 [1.13, 1.72]	0.62 [0.37, 0.98]	1.51 [0.85, 2.49]	1.07 [0.79, 1.42]	-	1.11 [0.87, 1.41]	0.76 [0.61, 0.92]	0.64 [0.32, 1.14]	1.10 [0.95, 1.27]
Melanoma	Obs	2134	1568	553	169	57	15	5	18	3	55	65	6	160
Melanoma	SMR [95% CI]	1.57 [1.50, 1.64]	3.69 [3.51, 3.88]	0.60 [0.55, 0.65]	0.52 [0.44, 0.60]	0.82 [0.62, 1.06]	0.27 [0.15, 0.44]	0.34 [0.11, 0.80]	0.38 [0.22, 0.60]	4.50 [0.93, 13.15]	1.04 [0.78, 1.35]	0.55 [0.42, 0.70]	0.46 [0.17, 0.99]	0.70 [0.60, 0.82]
Thyroid	Obs	945	427	514	166	37	26	18	18	1	26	58	2	162
Thyroid	SMR [95% CI]	0.96 [0.90, 1.03]	1.33 [1.21, 1.46]	0.78 [0.72, 0.85]	0.75 [0.64, 0.87]	0.72 [0.51, 0.99]	0.65 [0.42, 0.95]	1.53 [0.90, 2.41]	0.57 [0.34, 0.90]	1.03 [0.03, 5.76]	0.78 [0.51, 1.15]	0.70 [0.53, 0.90]	0.19 [0.02, 0.68]	0.95 [0.81, 1.11]
Other ¹	Obs	8112	5364	2489	809	269	133	72	100	4	99	253	25	725
Other ¹	SMR [95% CI]	4.16 [4.07, 4.26]	9.40 [9.15, 9.66]	1.82 [1.75, 1.89]	1.65 [1.54, 1.77]	2.33 [2.06, 2.62]	1.90 [1.59, 2.26]	3.04 [2.38, 3.83]	1.52 [1.24, 1.85]	3.76 [1.02, 9.62]	1.35 [1.09, 1.64]	1.44 [1.27, 1.63]	0.88 [0.57, 1.30]	2.23 [2.07, 2.40]

¹ Excluding Kaposi sarcoma. AYA = adolescent and young adult; Obs = observed deaths; SMR = standardized mortality ratio; 95% CI = 95% confidence interval. Note: Bolded SMRs are statistically significant.