Table 3.
Clinical phenotypes by LMX1B SNP rs187699205 among cases.
| Phenotype | GG (# Eyes) | Mean (SD) | GC (# Eyes) | Mean (SD) | Mean Difference (95% Confidence Interval) * |
p-Value |
|---|---|---|---|---|---|---|
| CCT | 4451 | 533.22 (39.72) | 107 | 537.66 (38.19) | −4.45 (−14.17 to 5.27) | 0.37 |
| CDR | 4476 | 0.71 (0.17) | 98 | 0.64 (0.18) | 0.07 (0.02 to 0.12) | 0.003 |
| IOP | 4769 | 17.39 (6.12) | 111 | 16.49 (5.28) | 0.90 (−0.43 to 2.23) | 0.19 |
| MD | 3781 | −8.47 (9.05) | 88 | −4.93 (6.39) | −3.54 (−5.00 to −2.08) | <0.001 |
| PSD | 3784 | 5.22 (3.47) | 88 | 4.59 (3.15) | 0.63 (−0.02 to 1.29) | 0.06 |
| RNFL | 3803 | 73.24 (15.03) | 92 | 75.07 (15.60) | −1.83 (−5.51 to 1.85) | 0.33 |
| VA (logMAR) | 4099 | 0.39 (0.85) | 92 | 0.41 (1.00) | −0.01 (−0.23 to 0.20) | 0.90 |
*: From GEE model: phenotype = intercept + genotype; VA = visual acuity; IOP = intraocular pressure; CCT = central corneal thickness; CDR = cup-to-disc ratio; RNFL = retinal nerve fiber layer; MD = mean deviation; PSD = pattern standard deviation.