FIG. 3.

Nucleotide sequences of Seq1 and Seq2 of the 59-bp intronic p53 response element of the mdm2 gene. Underlined are hexanucleotide sequences showing a high degree of homology to known native TREs, suggesting that the TRE in Seq1 is organized as a DR+4 TRE. The sequence underlined in Seq2 has on its complementary strand AGGACT. This is identical to sequences found in a TRE from the human thyroid-stimulating hormone α gene (10) and from the TRE sequences at positions −88 to −83 and −102 to −97 of the NF-κB binding sites of the HIV-1 LTR (15).