TABLE 1.

A T3R-responsive sequence is embedded within the p53 response element of the mdm2 gene^a

Transfection	CAT activityb
	Basal	T3
ΔMTV-CAT	0.3	0.4
+cT3Rα	0.2	0.3
+p53	0.2	NDc
ΔMTV-TREp-CAT	0.25	0.35
+cT3Rα	0.15	48.4
+p53	0.17	ND
ΔMTV-m59-CAT	0.19	0.24
+cT3Rα	0.3	46.7
+p53	54.6	ND
ΔMTV-Seq1-CAT	0.22	0.37
+cT3Rα	0.2	37.5
+p53	52.0	ND
ΔMTV-Seq2-CAT	0.3	0.36
+cT3Rα	0.2	3.0
+p53	6.5	ND

^aHeLa cells were transfected by electroporation with 5 μg of the indicated CAT reporter genes along with 4 μg of cT3Rα or p53 expression vector. Cells were incubated with and without 500 nM T3 and harvested for determination of CAT activity 48 h later. 

^bPercentage of [¹⁴C]chloramphenicol acetylated per 20 μg of cell protein in 16 h. 

^cND, not determined.