Table 1.
Main Aspect | Associated Markers | Stimulating Effect |
No Effect | Inhibiting Effect |
---|---|---|---|---|
Causers of oxidative stress |
Reactive oxygen species (including superoxide-ion and hydrogen peroxide) | [33,34,35,36,37,38,39,40,41] | [33,37,38,42,43] | [33,42,43,44] |
Nitric oxide synthase (NOS) (including endothelial NOS and inducible NOS) | [34,45,46,47,48] | [49,50,51] | [52,53,54] | |
Reactive nitrogen species (including nitric oxygen, nitrite and nitrate) | [33,34,45,49,55,56,57,58,59,60] | [33,46,61,62,63,64,65,66,67,68] | [53,61,67,68,69,70,71,72,73] | |
Hydrobenzoates | [74,75] | [74] | ||
Free fatty acid | [53] | |||
Myeloperoxidase | [34,62] | |||
Lipid peroxidation | Isoprostanes | [76,77] | [78,79] | |
Isofurans | [78] | |||
Malondialdehyde | [56,77,80,81,82] | [14,34,49,55,76,83] | [62,84] | |
Thiobarbituric acid reactive substances | [63,74,85,86,87] | [33,63,85,88,89,90] | ||
Lipid hydroperoxides | [36] | [91] | [92] | |
Oxidized low-density lipoprotein | [82] | |||
Protein peroxidation |
Nitrotyrosine | [49] | [64] | |
Advanced oxidation protein products | [77] | |||
Carbohydrate peroxidation |
Protein carbonyls | [93] | ||
Carbonyl group | [56] | |||
Protein carbonyl derivates | [55] | |||
Plasma carbonyl proteins | [83] | [82] | ||
DNA/RNA damage |
8-hydroxydeoxyguanosine | [83] | [82] | |
Tail moment | [38,94,95,96] | [76,97,98] | ||
Sister chromatid exchange | [14] | |||
Gene expression | Nuclear factor erythroid 2- related factor 2 | [45] | ||
Other residues of oxidative stress | Reactive oxygen metabolites | [80] | ||
Intracellular calcium concentration | [43] | |||
Antioxidants | Total antioxidant capacity | [91,93,94,99] | ||
Catalase | [33,34,43,45,55,62,81,100] | [43,55,62,63,76,83,89,94,97] | [63,80,85] | |
Superoxide dismutase | [55,56,81,84,100,101] | [14,33,55,62,63,76,83,89,94,97,102] | [80,85,86] | |
Glutathione | [92] | [76,80,83,94] | ||
Glutathione disulfide | [76,101] | |||
Glutathione reductase | [55,62] | |||
Glutathione peroxidase | [34,63,82,85] | [14,55,62,63,76,80,83,89,94,100] | [63] | |
Thiols | [88] | [93] | ||
Vitamin A | [80,94] | |||
Vitamin C | [94] | |||
Vitamin E | [80,94] | |||
Uric acid | [91,102] | [103] | ||
Heme oxygenase-1 | [45,95,96,97] | |||
NAD(P)H dehydrogenase [quinone] 1 | [45] |