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. 2021 Aug 14;11(8):1210. doi: 10.3390/biom11081210

Table 1.

The effect of HBOT on oxidative stress markers.

Main Aspect Associated Markers Stimulating
Effect
No Effect Inhibiting Effect
Causers of
oxidative stress
Reactive oxygen species (including superoxide-ion and hydrogen peroxide) [33,34,35,36,37,38,39,40,41] [33,37,38,42,43] [33,42,43,44]
Nitric oxide synthase (NOS) (including endothelial NOS and inducible NOS) [34,45,46,47,48] [49,50,51] [52,53,54]
Reactive nitrogen species (including nitric oxygen, nitrite and nitrate) [33,34,45,49,55,56,57,58,59,60] [33,46,61,62,63,64,65,66,67,68] [53,61,67,68,69,70,71,72,73]
Hydrobenzoates [74,75] [74]
Free fatty acid [53]
Myeloperoxidase [34,62]
Lipid peroxidation Isoprostanes [76,77] [78,79]
Isofurans [78]
Malondialdehyde [56,77,80,81,82] [14,34,49,55,76,83] [62,84]
Thiobarbituric acid reactive substances [63,74,85,86,87] [33,63,85,88,89,90]
Lipid hydroperoxides [36] [91] [92]
Oxidized low-density lipoprotein [82]
Protein
peroxidation
Nitrotyrosine [49] [64]
Advanced oxidation protein products [77]
Carbohydrate
peroxidation
Protein carbonyls [93]
Carbonyl group [56]
Protein carbonyl derivates [55]
Plasma carbonyl proteins [83] [82]
DNA/RNA
damage
8-hydroxydeoxyguanosine [83] [82]
Tail moment [38,94,95,96] [76,97,98]
Sister chromatid exchange [14]
Gene expression Nuclear factor erythroid 2- related factor 2 [45]
Other residues of oxidative stress Reactive oxygen metabolites [80]
Intracellular calcium concentration [43]
Antioxidants Total antioxidant capacity [91,93,94,99]
Catalase [33,34,43,45,55,62,81,100] [43,55,62,63,76,83,89,94,97] [63,80,85]
Superoxide dismutase [55,56,81,84,100,101] [14,33,55,62,63,76,83,89,94,97,102] [80,85,86]
Glutathione [92] [76,80,83,94]
Glutathione disulfide [76,101]
Glutathione reductase [55,62]
Glutathione peroxidase [34,63,82,85] [14,55,62,63,76,80,83,89,94,100] [63]
Thiols [88] [93]
Vitamin A [80,94]
Vitamin C [94]
Vitamin E [80,94]
Uric acid [91,102] [103]
Heme oxygenase-1 [45,95,96,97]
NAD(P)H dehydrogenase [quinone] 1 [45]